Studies Pertaining to the Clinical Aspects of Malaria :: Health, Diseases

STUDIES PERTAINING TO THE CLINICAL ASPECTS OF MALARIAMalaria is a complex condition exhibiting divers(prenominal) manifestations in diverse parts of the world depending on a hardly a(prenominal) variables (Bin Mohanna et al. 2007). It was prove that anemia and splenomegaly are significantly associated with malaria among asymptomatic schoolchildren in Hajr valley, Hadramout (Bin Mohanna et al. 2007). Agina and Abd-Allah (1999) conducted a case control study for the association of nitric oxide levels to the severity and outcomes of noetic malaria in Yemeni in-patients. The main clinical presentations in cerebral malaria patients were fever (76.4%), pallor (72.0%), hypoglycemia (67.4%), splenomegaly (60.5%), deep syncope (39.5%), jaundice (18.6%), pulmonary dropsy (13.9%), subconjunctival hemorrhage (13.9%), severe anemia (53.5%), and haemoglobinuria (6.9%) while in non-cerebral malaria patients the clinical presentations were fever (83.8%), pallor (67.7%), splenomegaly (66.0 %), jaundice (9.7%), severe anemia (51.6%) and hypoglycemia (3.2%) . The serum level of nitric oxide was found to be higher in patients with cerebral malaria than those without. In cerebral malaria, nitric oxide levels were highly elevated in patients with deeper coma and longer duration of coma as well as those who died of cerebral malaria indicating its association with indices of disease severity and outcome in patients with cerebral malaria (Agina and Abd-Allah, 1999).Sheiban et al. (1998) study severe acute renal also-ran secondary to falciparum malaria among children receiving antimalarial therapy and some other supportive therapy as well as peritoneal dialysis referred to the renal unit at Al-Thawra Hospital in Sanaa. In this study, it was concluded that significant differences were found between children who died (43.8%) compared to those who survived regarding age, plasma creatinine, plasma bilirubin, systolic and diastolic blood pressure, hemoglobin concentration, urin e output, and time from diagnosis to referral. However, gender, alanine aminotransferase level, degree of fever, plasma atomic number 11 or potassium levels were not found to be statistically different between these two groups (Sheiban et al. 1998). The author found that previous immunity, as indicated by presence of splenomegaly, was associated with better prognosis both in terms of set out mortality and less hemodynamic disturbance which was evident in the older children owe to previous exposure to malarial infection, and therefore development of immunity (Sheiban et al. 1998). It is principal(prenominal) to note that malaria was reported to be the cause of 5.9% of chronic renal mischance in patients undergoing regular hemodialysis in Hadramout governorate (Badheeb 1998). Recently, Al Rohani et al. (2011) reported that malaria is the around common infectious disease causing acute renal failure (ARF) in Yemeni patients.